PDRN Treatment: Polynucleotide Biorevitaliser for Skin Repair

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PDRN Treatment: Polynucleotide Biorevitaliser for Skin Repair

PDRN Treatment for Cellular Skin Rejuvenation

PDRN (polydeoxyribonucleotide) is a biorevitaliser made from purified DNA fragments derived from salmon, which is why it is often called a salmon DNA treatment. Rather than adding volume like a dermal filler, PDRN works within the dermis, where it is thought to support the skin’s own repair processes: fibroblast activity, collagen production, hydration and microcirculation. [CTA Button: Book a Consultation]

At AAYNA, PDRN treatment is planned by a dermatologist and aesthetic physician and delivered into the skin through fine microchannels, under numbing cream, in about 45 to 60 minutes. It suits skin that looks tired, thin, sun-damaged or slow to recover, common ageing and skin quality concerns, and it is often used to support recovery after other procedures.

Often paired with: Derma Genesis DERMAFRAC, AAYNA Renew, GFC Skin Treatment, Skin Boosters.

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Treatment For

Dull or tired skin quality, dehydration, early signs of ageing, sun and environment damage, post-procedure recovery

Treatment Areas

Face, neck, décolletage and under-eye area

Duration

45 to 60 minutes

Frequency

Typically 3 to 4 sessions, 2 to 4 weeks apart, then maintenance every 3 to 6 months

Disclaimer: Results may vary based on individual skin type, age, lifestyle, and health history.

Top Benefits of PDRN Treatment

Deep Cellular Regeneration

Collagen and Elastin Stimulation

Improved Skin Hydration

Vascular Renewal Anti-Inflammatory Effect

Restores Skin Vitality

Minimal Downtime

Biocompatible, Well-Tolerated

PDRN Treatment Process: Step-by-Step

Step 1

Skin Assessment

Your specialist evaluates the skin's hydration, elasticity, and overall quality. PDRN is most effective when the specific deficit, whether hydration, collagen density, or tissue vitality, is clearly identified.

Step 2

Topical Numbing

A topical anaesthetic is applied and allowed to take effect. PDRN is delivered by fine injection, and numbing ensures consistent comfort throughout.

Step 3

Derma Pen Application

PDRN is infused into the skin using a Derma Pen, which creates microchannels to enhance product penetration and absorption across the treatment area.

Step 4

Calm and Protect

A soothing cream and SPF are applied. Mild redness and small raised marks at injection sites resolve within a few hours.

PDRN Treatment: Before and After

Key Features of PDRN Treatment

Salmon-derived PDRN

Purified polydeoxyribonucleotide with high biocompatibility with human tissue

Salmon-derived PDRN

Purified polydeoxyribonucleotide with high biocompatibility with human tissue

A2A receptor activation

Triggers the body's own tissue repair and regeneration cascade

A2A receptor activation

Triggers the body's own tissue repair and regeneration cascade

Collagen synthesis

Increases fibroblast activity and dermal collagen production

Collagen synthesis

Increases fibroblast activity and dermal collagen production

Vascular improvement

Stimulates microvascularisation, improving nutrient delivery to the skin

Vascular improvement

Stimulates microvascularisation, improving nutrient delivery to the skin

Deep hydration

improves the skin's capacity to retain moisture at the dermal level

Deep hydration

improves the skin's capacity to retain moisture at the dermal level

Anti-inflammatory effect

Reduces chronic low-grade dermal inflammation that accelerates ageing

Anti-inflammatory effect

Reduces chronic low-grade dermal inflammation that accelerates ageing

Combinable

Frequently used with microneedling or MNRF to enhance delivery and absorption

Combinable

Frequently used with microneedling or MNRF to enhance delivery and absorption

Polynucleotide Biorevitaliser Treatment (PDRN) FAQs

What is PDRN made from?

PDRN treatment uses polydeoxyribonucleotide, purified DNA fragments sourced from salmon, delivered into the skin to support repair, hydration and collagen production. It is a biorevitaliser rather than a filler.

How is PDRN different from hyaluronic acid fillers or skin boosters?

Hyaluronic acid skin boosters primarily improve surface hydration and add volume. PDRN works at a cellular level, activating the tissue’s own repair mechanisms rather than supplying a structural substance. The improvement in skin quality is more intrinsic and biological.

How many sessions are needed?

Three to four sessions spaced two to four weeks apart is the standard initial course. Maintenance sessions every three to six months sustain the cellular benefit.

Is there downtime?

Minimal. Small injection marks and mild redness resolve within a few hours. The skin may feel slightly warm or tight for a day. Normal activity resumes the same day.

Can PDRN be combined with other treatments?

Yes. PDRN is frequently delivered through microneedling or MNRF channels immediately after the procedure, significantly enhancing absorption. It also pairs well with GFC and exosome therapy as part of a comprehensive regenerative protocol.

Is PDRN suitable for all skin types?

Yes. It is well-tolerated across all skin tones and is particularly beneficial for mature skin, post-procedure recovery, and skin that has been exposed to chronic sun damage or environmental stress. People with history of severe fish allergy may be advised against the treatment

Is PDRN the same as salmon DNA or polynucleotides?

These terms are closely related. PDRN and polynucleotides (PN) are both derived from salmon DNA, but they differ in fragment size and how they are processed. Your doctor will explain which product is used in your plan.

How much does PDRN treatment cost?

Cost depends on the product, the number of areas (face, neck, under-eye), how many sessions are recommended and whether PDRN is combined with microneedling or other treatments. A consultation allows your doctor to give an accurate quote.

How many PDRN sessions will I need?

An initial course is usually 3 to 4 sessions, 2 to 4 weeks apart, followed by maintenance every 3 to 6 months. Your doctor will tailor this to your skin.