PDRN — Polynucleotide Biorevitaliser

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PDRN — Polynucleotide Biorevitaliser

PDRN Treatment

Skin regeneration depends on cellular signalling. Cells need instruction to repair, produce collagen, and maintain the structural proteins that keep skin firm, hydrated, and resilient. PDRN provides that instruction at a molecular level.

PDRN, or Polydeoxyribonucleotide, is derived from purified salmon sperm DNA fragments.. The molecular structure of salmon PDRN is highly compatible with human tissue, and once delivered into the skin, it activates the A2A adenosine receptor pathway, a key mechanism in tissue repair and regeneration. The result is accelerated cellular turnover, increased collagen synthesis, improved vascular supply to the treated tissue, and a measurable improvement in skin hydration, elasticity, and overall quality.

PDRN is used at AAYNA as a biorevitaliser, meaning it works from within the dermis to restore the skin’s biological function rather than simply filling or volumising it. It is suited to skin that has lost vitality, resilience, and quality of hydration, often the precursors to visible ageing.

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Treatment For

Skin quality, hydration, early ageing, tissue vitality

Treatment Areas

Face, neck, décolletage, under eyes

Duration

45–60 min

Frequency

Every 2–4 weeks; 3–4 sessions initial course

Disclaimer: Results may vary based on individual skin type, age, gender, lifestyle, and health history.

Top Benefits of PDRN Treatment

Deep Cellular Regeneration

Collagen and Elastin Stimulation

Improved Skin Hydration

Vascular Renewal Anti-Inflammatory Effect

Restores Skin Vitality

Minimal Downtime

Biocompatible, Well-Tolerated

Steps of PDRN Treatment

Step 1

Skin Assessment

Your specialist evaluates the skin's hydration, elasticity, and overall quality. PDRN is most effective when the specific deficit, whether hydration, collagen density, or tissue vitality, is clearly identified.

Step 2

Topical Numbing

A topical anaesthetic is applied and allowed to take effect. PDRN is delivered by fine injection, and numbing ensures consistent comfort throughout.

Step 3

Derma Pen Application

PDRN is infused into the skin using a Derma Pen, which creates microchannels to enhance product penetration and absorption across the treatment area.

Step 4

Calm and Protect

A soothing cream and SPF are applied. Mild redness and small raised marks at injection sites resolve within a few hours.

PDRN Treatment Features

Salmon-derived PDRN

Purified polydeoxyribonucleotide with high biocompatibility with human tissue

Salmon-derived PDRN

Purified polydeoxyribonucleotide with high biocompatibility with human tissue

A2A receptor activation

Triggers the body's own tissue repair and regeneration cascade

A2A receptor activation

Triggers the body's own tissue repair and regeneration cascade

Collagen synthesis

Increases fibroblast activity and dermal collagen production

Collagen synthesis

Increases fibroblast activity and dermal collagen production

Vascular improvement

Stimulates microvascularisation, improving nutrient delivery to the skin

Vascular improvement

Stimulates microvascularisation, improving nutrient delivery to the skin

Deep hydration

improves the skin's capacity to retain moisture at the dermal level

Deep hydration

improves the skin's capacity to retain moisture at the dermal level

Anti-inflammatory effect

Reduces chronic low-grade dermal inflammation that accelerates ageing

Anti-inflammatory effect

Reduces chronic low-grade dermal inflammation that accelerates ageing

Combinable

Frequently used with microneedling or MNRF to enhance delivery and absorption

Combinable

Frequently used with microneedling or MNRF to enhance delivery and absorption

PDRN FAQs

What is PDRN made from?

PDRN is derived from purified salmon sperm DNA. The molecular structure is highly biocompatible with human tissue, and the purification process ensures it is safe for clinical use excepting in people with seafood or fish allergy There is no detectable protein content, which eliminates the risk of allergic reaction.

How is PDRN different from hyaluronic acid fillers or skin boosters?

Hyaluronic acid skin boosters primarily improve surface hydration and add volume. PDRN works at a cellular level, activating the tissue’s own repair mechanisms rather than supplying a structural substance. The improvement in skin quality is more intrinsic and biological.

How many sessions are needed?

Three to four sessions spaced two to four weeks apart is the standard initial course. Maintenance sessions every three to six months sustain the cellular benefit.

Is there downtime?

Minimal. Small injection marks and mild redness resolve within a few hours. The skin may feel slightly warm or tight for a day. Normal activity resumes the same day.

Can PDRN be combined with other treatments?

Yes. PDRN is frequently delivered through microneedling or MNRF channels immediately after the procedure, significantly enhancing absorption. It also pairs well with GFC and exosome therapy as part of a comprehensive regenerative protocol.

Is PDRN suitable for all skin types?

Yes. It is well-tolerated across all skin tones and is particularly beneficial for mature skin, post-procedure recovery, and skin that has been exposed to chronic sun damage or environmental stress. People with history of severe fish allergy may be advised against the treatment